Background: Guidance for postabortion care (PAC) is established for the first trimester but limited in the second trimester. Objective: To establish evidence-based recommendations for PAC in the second trimester. Conclusion: Misoprostol with or without mifepristone is an effective treatment for second-trimester PAC. The minimum misoprostol dose is 200 μg vaginally, sublingually, or buccally every 6–12 hours.