This reference guide provides information and recommendations based on evidence for medical abortion at or after 13 weeks gestation, sometimes called induction abortion or termination in the second trimester, using misoprostol-based regimens (mifepristone plus misoprostol or misoprostol only) for women who need either induced abortion, treatment of incomplete abortion or postabortion care. Health-care providers with previous experience providing high-quality, first-trimester abortion services who want to expand their skills to care for women at or after 13 weeks gestation using medical abortion are the primary audience for this guide.