Research has not kept abreast of women’s self-use of medical abortion, leaving many gaps in the scientific literature regarding the ideal conditions for safe and effective use. In December 2016, a group of 20 global abortion researchers convened following the Africa Regional Conference on Abortion to discuss current and future research on medical abortion self-use. This article lays out their list of identified research gaps and methodologic considerations in addressing them—challenges that are intended to inform both ongoing and future research.